The Saint Louis Surgical Society was founded in 1892 when the first meeting was held at the home of Dr. E. H. Gregory. Its membership was limited to 12 surgeons of the Saint Louis Community. The early goals were stated in the inaugural address of Dr. Gregory who said, "As surgeons...there is no calling which demands wider or more comprehensive information".

In this spirit, the society has grown to nearly 150 active members and sponsors forums and lectures for retired and practicing clinicians, surgical residents and students.